Antibodies generated against purified cell membrane proteins or peptides often do not recognize the target when displayed on the surface of a cell.
This limits their use in research, diagnostics, and therapeutics for targeting important classes of molecules, including ion channels, G-protein coupled receptors, receptor tyrosine kinases, integrins, and toll-like receptor proteins.
AxioMx Inc. has overcome this challenge by applying its unique phage display-based antibody development platform to whole cell screening to isolate membrane protein-specific antibodies that recognize the extracellular domains (ECDs) in their native conformations.
- About AxioMx’s MembraneProSelect System for developing antibodies that bind to the native conformation membrane protein ECDs
- How we applied the system to develop a specific, anti-receptor tyrosine kinase antibody