Develop Antibodies that Recognize the Native Conformations of Cell Membrane Protein Extracellular Domains

Antibodies generated against purified cell membrane proteins or peptides often do not recognize the target when displayed on the surface of a cell.

This limits their use in research, diagnostics, and therapeutics for targeting important classes of molecules, including ion channels, G-protein coupled receptors, receptor tyrosine kinases, integrins, and toll-like receptor proteins.

AxioMx Inc. has overcome this challenge by applying its unique phage display-based antibody development platform to whole cell screening to isolate membrane protein-specific antibodies that recognize the extracellular domains (ECDs) in their native conformations.

Learn:

  • About AxioMx’s MembraneProSelect System for developing antibodies that bind to the native conformation membrane protein ECDs
  • How we applied the system to develop a specific, anti-receptor tyrosine kinase antibody